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研究成果

2023

  • *Ishida T, *Ueyama T, Ihara D, Harada Y, Nakagawa S, Saito K, NakaoS, Kawamura T. c-Myc/microRNA-17-92 axis phase-dependently regulates PTEN and p21 expression via ceRNA during reprogramming to mouse pluripotent stem cells. Biomedicines 2023;11:1737 (*equally contributed)

  • *Sogo T, *Nakao S, Tsukamoto T, Ueyama T, Harada Y, Ihara D, Ishida T, Nakahara M, Hasegawa K, Akagi Y, Kida Y, Nakagawa O, Nagamune T, Kawahara M, Kawamura T. Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells. Inflamm Regen 2023;43:11 (*equally contributed)

2021

  • Boyett MR, Yanni J, Tellez J, Bucchi A, Mesirca P, Cai X, Logantha SJRJ, Wilson C, Anderson C, Ariyaratnam J, Stuart L, Nakao S, Allah EA, Jones S, Lancaster M, Stephenson R, Chandler N, Smith M, Bussey C, Monfredi O, Morris G, Billeter R, Mangoni ME, ZHang H, Hart G, D'Souza A. Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease. Prog Biophys Mol Biol 2021;166:61-85

  • Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes to Cells 2021 2021;26:611-626

  • Logantha SJRJ, Cai X, Yanni J, Jones C, Stephenson R, Stuart L, Quigley G, Monfredi O, Nakao S, Oh IY, Starborg T, Kitmitto A, Vohra A, Hutcheon R, Corno A, Jarvis J, Dobrzynski H, Boyett M, Hart G. Remodelling of the Purkinje network in congestive heart failure in the rabbit. Circ Heart Failure 2021;14:e007505

  • *Mesirca P, *Nakao S, *Nissen SD, Forte G, Anderson C, Trussell T, Li J, Cox C, Zi M, Logantha SJR, Yaar S, Carstensen H, Bidaud I, Stuart L, Soattin L, Morris GM, da Costa Martins PA, Cartwright EJ, Oceandy D, Mangoni ME, Jespersen T, Buhl R, Dobrzynski H, Boyett MR, D'Souza A. Intrinsic electrical remodeling underlies atrioventricular block in athletes. Circ Res 2021;129:e1-e20 (*equally contributed)

  • *Nakao S, *Atkinson AJ, Motomochi T, Fukunaga D, Dobrzynski H. Common arterial trunk in a cat. A high-resolution morphological analysis with micro-computed tomography. J Vet Cardiol 2021;34:8-15 (*equally contributed)

2020

  • Yanni J, D'Souza A, Wang Y, Li N, Hansen BJ, Zakharkin SO, Smith M, Hayward C, Whitson BA, Mohler PJ, Janssen PML, Zeef L, Choudhury M, Zi M, Cai X, Logantha SJRJ, Nakao S, Atkinson A, Petkova M, Doris U, Ariyaratnam J, Cartwright EJ, Griffiths-Jones S, Hart G, Fedrov VV, Oceandy D, Dobrzynski H, Boyett MR. Silencing miR-370-3p rescues funny current and sinus node function in heart failure. Sci Rep 2020;10:11279

  • Ishida T, Nakao S, Ueyama T, Harada Y, Kawamura T. Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1. Inflamm Regen 2020;40:8

  • Nakao S, Tsukamoto T, Ueyama T, Kawamura T. STAT3 for cardiac regenerative medicine: involvement in stem cell biology, pathophysiology, and bioengineering. Int J Mol Sci 2020;21:1937

  • Nakao S, Ihara D, Hasegawa K, Kawamura T. Applications of induced pluripotent stem cells in disease modelling and drug development for heart diseases. Eur Cardiol Rev 2020;15:e02

  • 中尾周、宮﨑聖也、水口幹公、柳澤和輝、川村晃久．洞房結節におけるインパルス生成の分子基盤と臨床．動物の循環器 2020;53(2):53-63

  • 佐々木崇文、中尾周、木村勇介、平川篤、町田登．猫の第3度房室ブロック症例にみられた房室伝導系病変．日本獣医師会雑誌 2020;73(6):315-320

2019

  • Tsukamoto T, Sogo T, Ueyama T, Nakao S, Harada Y, Ihara D, Akagi Y, Kida YS, Hasegawa K, Nagamune T, Kawahara M, Kawamura T. Chimeric G-CSF receptor-mediated STAT3 activation contributes to efficient induction of cardiomyocytes from mouse induced pluripotent stem cells. Biotechnol J 2019;2019:e1900052

  • Nakamura TY, Nakao S, Wakabayashi S. Emerging roles of neuronal Ca2+ sensor-1 in cardiac and neuronal tissues. Front Mol Neurosci 2019;12:56

2018

  • Li J, Mesirca P, D'Souza A, Wang Y, Nakao S, Cox C, Hancox J, Mangoni M, Boyett MR. Heart block in the athlete -role of ion channel remodelling as studied using a one-dimensional computational model of the atrioventricular node. Comput Cardiol 2018;45:1-4

  • Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du CK, Zhan DY, Nakao S, Machida N, Tanaka R, Yamane Y, Hayashi T, Kimura A. Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance. Am J Physiol Heart Circ Physiol 2018;314(6):H1192-H1212

  • Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O. Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 2018;21:415-423

2017

  • D’Souza A, Pearman C, Wang Y, Nakao S, Logantha SJ, Cox C, Bennett H, Zhang Y, Johnsen AB, Elliott J, Coulson J, McPhee J, Robertson A, Da Costa Martins P, Kitmitto A, Wisloff U, Cartwright EJ, Monfredi O, Dobrzynski H, Oceandy D, Morris GM, Boyett MR. Targeting miR-423-5p reverses exercise training-induced HCN4 channel remodelling and sinus bradycardia. Circ Res 2017;121:1058-1068

  • Boyett MR, Wang Y, Nakao S, Ariyaratnam J, Hart G, Monfredi O, D'Souza A. Rebuttal from Boyett et al. J Appl Physiol (1985) 2017;123(3):689

  • Boyett MR, Wang, Y, Nakao S, Ariyaratnam J, Hart G, Monfredi O, D’Souza A, Billman G. Point: Exercise training-induced bradycardia is/is not caused by changes in intrinsic sinus node function. J Appl Physiol (1985) 2017;123(3):684-685

  • Boyett MR, Wang, Y, Nakao S, Ariyaratnam J, Hart G, Monfredi O, D’Souza A, Billman G. Exercise training-induced bradycardia is/is not caused by changes in intrinsic sinus node function. J Appl Physiol (1985) 2017;jap002682017

  • Nakamura TY, Nakao S, Nakajo Y, Takahashi JC, Wakabayashi S, Yanoamoto H. Possible signaling pathways mediating neuronal calcium sensor-1-dependent spatial learning and memory in mice. PLoS ONE 2017;12(1):e0170829

2016

  • Nakamura TY, Nakao S, Wakabayashi S. Neuronal Ca2+ sensor-1 contributes stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways. J Mol Cell Cardiol 2016;99:23-34

  • Kimura Y, Hirakawa A, Nakao S, Kobayashi M, Machida N. Feline endomyocardial restrictive cardiomyopathy occurring in one sibling pair. 動物の循環器 2016;49(2):77-80

2015

  • Nakao S, Wakabayashi S, Nakamura TY. Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes. PLoS ONE 2015;10(4):e0125050

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